Structure of PDB 6ncs Chain A Binding Site BS01

Receptor Information
>6ncs Chain A (length=285) Species: 355277 (Leptospira borgpetersenii serovar Hardjo-bovis str. JB197) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMSQEITLGNIKIGGNNPVFIIAEAGLNHGGDLNLALRMIDEAADAKA
NAIKFQAYNSEERFGENKEAVNLVKPAEFGKKEFLLLKERSQKKNILFFA
TPFDVPNLNMLKEIGVEILKIASCDICNITLLEAAADSGLIVILSRGTAS
ASEIETAVSIFKKKKSPFILLHCVSSYPMNEIDANLSAIQTLKSKYEFPI
GYSDHSKGIEIPLLAVASGAEIIEKHYTVDRTLQGIDWEISAEPKELAKL
VTETERIRKILGHGKLEPQASEQEEIEYRNSLRRK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6ncs Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ncs Crystal structure of N-acetylneuraminic acid (Sialic acid) synthetase from Leptospira borgpetersenii serovar Hardjo-bovis in complex with citrate
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H202 H223
Binding residue
(residue number reindexed from 1)		H205 H226
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
GO:0047444 N-acylneuraminate-9-phosphate synthase activity
Biological Process
GO:0016051 carbohydrate biosynthetic process
GO:0070085 glycosylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ncs, PDBe:6ncs, PDBj:6ncs
PDBsum6ncs
PubMed
UniProtQ04TM5

[Back to BioLiP]