Structure of PDB 6n22 Chain A Binding Site BS01

Receptor Information

>6n22 Chain A (length=231) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELS
LKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVG
TVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA
TDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKT
RYYVIIQANDRAQNLNERRTTTTTLTVDVLD

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6n22 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6n22 Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	E27 E28 D83 D85 D121
Binding residue (residue number reindexed from 1)	E22 E23 D78 D80 D116
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007605	sensory perception of sound
GO:0048839	inner ear development

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032420	stereocilium

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6n22, PDBe:6n22, PDBj:6n22
PDBsum	6n22
PubMed	32963095
UniProt	Q99PJ1\|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)

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