Structure of PDB 6mzm Chain A Binding Site BS01

Receptor Information

>6mzm Chain A (length=445) Species: 9606 (Homo sapiens)

IIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQ
PLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEEN
GPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPG
QLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCP
LFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSH
SESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCA
YYSMIAAEQRLKDAGYGEKSFKIDDEVRTAPWNTTRAFIAAMKGKCLLEV
TGVADPTGCGEGFSYVKIPNKDADLRRLSLKNAKQLLRKFGVPEEEIKKL
SRWEVIDVVRTMSTESVAEHQERYKEECQRIFDLQNKVLSSTEVL

Ligand information

>6mzm Chain U (length=80)

ccgtaggcacgtctgctcggctcgagtgttcgatcgcgactgaggacgaa
cgcgcccccacccccttttataggcgccct

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6mzm Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
• Resolution: 7.5 Å
• Binding residue (original residue number in PDB): K797 E839 R843 F852 W862 R1022
• Binding residue (residue number reindexed from 1): K210 E252 R256 F265 W275 R402

Enzymatic activity

• Enzyme Commision number: 2.3.1.48: histone acetyltransferase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity
• GO:0016251 RNA polymerase II general transcription initiation factor activity
• GO:0017025 TBP-class protein binding

Biological Process

• GO:0006366 transcription by RNA polymerase II

Cellular Component

• GO:0005669 transcription factor TFIID complex

External links

• PDB: RCSB:6mzm, PDBe:6mzm, PDBj:6mzm
• PDBsum: 6mzm
• PubMed: 30442764
• UniProt: P21675|TAF1_HUMAN Transcription initiation factor TFIID subunit 1 (Gene Name=TAF1)