Structure of PDB 6mus Chain A Binding Site BS01

Receptor Information
>6mus Chain A (length=772) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIDELTALGGLLANIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEYE
LLSLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEAD
NLASGERPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYR
ELVKRLWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMT
SAIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGT
LKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPD
AVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEA
RKRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSA
SDPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYL
QGGRPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEEL
SMASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGA
IIEGKFGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFR
VRRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRV
FVVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGL
LWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVER
KEPQPVYWVDGVLKIVLMAVRR
Ligand information
>6mus Chain H (length=25) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caauacgcaaaccgccucugcccgc
.........................
Receptor-Ligand Complex Structure
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PDB6mus Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R630 S701 R777
Binding residue
(residue number reindexed from 1)		R625 S696 R772
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6mus, PDBe:6mus, PDBj:6mus
PDBsum6mus
PubMed30503773
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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