Structure of PDB 6mu5 Chain A Binding Site BS01

Receptor Information
>6mu5 Chain A (length=578) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLRP
ETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLAA
YLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHLV
RKAAAIWALERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDTK
RLEQMGEELAEQLRTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVLK
KTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPD
TKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWL
IFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVT
PNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKR
YMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQG
SAADIIKKAMIDLNARLKEERLQARLLLQVHDELILEAPKEEMERLCRLV
PEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6mu5 Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.
Resolution1.912 Å
Binding residue
(original residue number in PDB)		T550 K551 T552 S555 T556 S557 A558 R578 K582 Y587 R615 N625 I626 P627 I628 R629 F710 Y714 V828 H829 D830
Binding residue
(residue number reindexed from 1)		T252 K253 T254 S257 T258 S259 A260 R280 K284 Y289 R317 N327 I328 P329 I330 R331 F412 Y416 V530 H531 D532
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004518 nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6mu5, PDBe:6mu5, PDBj:6mu5
PDBsum6mu5
PubMed31170294
UniProtE1C9K5

[Back to BioLiP]