Structure of PDB 6mq8 Chain A Binding Site BS01

Receptor Information
>6mq8 Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB6mq8 Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Resolution1.969 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 K86 R93 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q37 Y38 W41 K85 R92 K305 R307 P310 K311 T312 G314 S316 K317 N318 P320 G321 R345
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6mq8, PDBe:6mq8, PDBj:6mq8
PDBsum6mq8
PubMed33258913
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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