Structure of PDB 6mn8 Chain A Binding Site BS01

Receptor Information

>6mn8 Chain A (length=399) Species: 6282 (Onchocerca volvulus)

AHHHHHHIEISKDENYSEWYVQVITKAEMIEYYDISGCYVLRPWSYAIWE
FIQEWFDEEIKKLGVKNCYFPLFVSQSALEKEFAPEVAWITRAGQSDLAE
AIAIRPTSETVMYPSYAKWVQSHRDLPIKLNQWCNVVRWEFKHPTPFLRT
REFLWQEGHTAFQSKDEAEDEVFKILDLYAQIYIDLLAIPVIKGRKGGDF
TATVEAYVPVNGRGIQGATSHHLGQNFSKMFNISFEDPNGGGKIYAWQNS
WGISTRTIGALVMIHGDNCGLVLPPRVATIQMIIVPVGITKDEQKTALIE
KAKEINNKLMDASIRAELDIRDHISPGWKFNHWELKGVPVRIEIGPKDLA
NNQVTCVIRYSGEKRTIPIDGLASKCKDMLEEIHYSMYNRILEVRESHT

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6mn8 Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6mn8 Crystal Structure of Prolyl-tRNA Synthetase from Onchocerca volvulus with bound Halofuginone and nucleotide
• Resolution: 2.35 Å
• Binding residue (original residue number in PDB): V172 S293
• Binding residue (residue number reindexed from 1): V120 S234
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.15: proline--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004827 proline-tRNA ligase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006433 prolyl-tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0017101 aminoacyl-tRNA synthetase multienzyme complex

External links

• PDB: RCSB:6mn8, PDBe:6mn8, PDBj:6mn8
• PDBsum: 6mn8
• UniProt: A0A2K6VKP7