Structure of PDB 6ml1 Chain A Binding Site BS01

Receptor Information
>6ml1 Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEQPGLCGLSNLGFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMR
GEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFCQELLAFLLDGL
HEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLF
KSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLKDCIELFTTKEKLG
DPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDF
PINDLDMSGCRYNLIAVSNHYGGHYTAFAKNKDDGKWYYFDDSSVSTASE
DQIVSKAAYVLFYQRQ
Ligand information
Receptor-Ligand Complex Structure
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PDB6ml1 Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W825 S826 L827 S862 G872
Binding residue
(residue number reindexed from 1)		W221 S222 L223 S258 G259
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6ml1, PDBe:6ml1, PDBj:6ml1
PDBsum6ml1
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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