Structure of PDB 6mf6 Chain A Binding Site BS01
Receptor Information
>6mf6 Chain A (length=244) Species:
559292
(Saccharomyces cerevisiae S288C) [
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AQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGL
PKSRLPKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTVLRLAD
AEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLHKD
DVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHE
STTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD
Ligand information
>6mf6 Chain C (length=8) Species:
559292
(Saccharomyces cerevisiae S288C) [
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RSIEGAVQ
Receptor-Ligand Complex Structure
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PDB
6mf6
Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division.
Resolution
3.4 Å
Binding residue
(original residue number in PDB)
W555 W565 V566 D611 D612 F614 R616 S630
Binding residue
(residue number reindexed from 1)
W105 W115 V116 D150 D151 F153 R155 S169
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:6mf6
,
PDBe:6mf6
,
PDBj:6mf6
PDBsum
6mf6
PubMed
32099015
UniProt
P32562
|CDC5_YEAST Cell cycle serine/threonine-protein kinase CDC5/MSD2 (Gene Name=CDC5)
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