Structure of PDB 6mf5 Chain A Binding Site BS01
Receptor Information
>6mf5 Chain A (length=250) Species:
559292
(Saccharomyces cerevisiae S288C) [
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AQRRLNDLAREARIRRAQQAVLRKELIATSTNVIKSEISLRILASECHLT
LNGIVEAEAQYKIKHPMIVTKWVDYSNKHGFSYQLSTEDIGVLFNNGTTV
LRLAEEFWYISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANL
SRVSTKDDVFLRRYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVT
YISPSHESTTYPLVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTV
Ligand information
>6mf5 Chain C (length=7) Species:
4932
(Saccharomyces cerevisiae) [
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LAQSSPA
Receptor-Ligand Complex Structure
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PDB
6mf5
Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
K516 W517 D519 Y520 Y592 N596 L597 S598 R620 H641 K643
Binding residue
(residue number reindexed from 1)
K71 W72 D74 Y75 Y145 N149 L150 S151 R166 H187 K189
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:6mf5
,
PDBe:6mf5
,
PDBj:6mf5
PDBsum
6mf5
PubMed
32099015
UniProt
P32562
|CDC5_YEAST Cell cycle serine/threonine-protein kinase CDC5/MSD2 (Gene Name=CDC5)
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