Structure of PDB 6mcb Chain A Binding Site BS01

Receptor Information
>6mcb Chain A (length=1364) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALL
FDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE
ESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLR
LIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPIN
ASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNF
KSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILL
SDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFF
DQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQ
RTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYV
GPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNL
PNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLL
FKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIK
DKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLK
RRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSL
TFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMG
RHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVE
NTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSI
DNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTK
AERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIRE
VKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYP
KLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITL
ANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQT
GGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKG
KSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYS
LFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDN
EQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPI
REQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSI
TGLYETRIDLSQLG
Ligand information
>6mcb Chain B (length=116) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgcauaaagaugagacgcguuuuagagcuaugcuguuuugaaaaaaac
agcauagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaagugg
caccgagucggugcuu
....................<<<<<<..<<<<<<<<.<<<.....>>>..
>>>>>>>>....>>>>>>..<<.....>>.......<<<<....>>>>.<
<<<<<...>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mcb Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K30 K33 L35 I43 K44 N46 E57 T58 A59 T62 R63 K65 R66 R69 R70 R71 Y72 R74 R75 K76 N77 R78 L101 S104 F105 K111 R115 H116 I122 E125 V126 H129 T134 I135 H160 K163 F164 R165 G166 Y325 H328 H329 K336 R340 K348 F351 F352 Y359 I363 Q402 R403 T404 F405 N407 G408 F446 R447 I448 Y450 P454 L455 A456 R457 N459 S460 F462 W464 R467 T472 I473 M495 N497 R661 N692 M694 A728 G729 S730 K735 Q739 K742 K749 R753 N767 S851 D853 T893 R895 R919 T924 Q926 K959 S960 K968 K974 Y981 M1089 P1090 Q1091 K1097 E1099 T1102 G1103 G1104 F1105 I1110 P1112 K1113 R1122 K1123 K1124 Y1131 M1169 A1227 Q1272 H1349 Q1350 S1351 Y1356 T1358
Binding residue
(residue number reindexed from 1)		K28 K31 L33 I41 K42 N44 E55 T56 A57 T60 R61 K63 R64 R67 R68 R69 Y70 R72 R73 K74 N75 R76 L99 S102 F103 K109 R113 H114 I120 E123 V124 H127 T132 I133 H158 K161 F162 R163 G164 Y323 H326 H327 K334 R338 K346 F349 F350 Y357 I361 Q400 R401 T402 F403 N405 G406 F444 R445 I446 Y448 P452 L453 A454 R455 N457 S458 F460 W462 R465 T470 I471 M493 N495 R659 N690 M692 A726 G727 S728 K733 Q737 K740 K747 R751 N765 S849 D851 T891 R893 R917 T922 Q924 K957 S958 K966 K972 Y979 M1087 P1088 Q1089 K1095 E1097 T1100 G1101 G1102 F1103 I1108 P1110 K1111 R1120 K1121 K1122 Y1129 M1167 A1225 Q1270 H1347 Q1348 S1349 Y1354 T1356
Gene Ontology
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UnboundLocalError		Python 3.6.8: /usr/bin/python3
Fri Nov 15 13:48:04 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()
   1435     title=pdb2title(pdbid)
   1436     if bs.startswith("BS"):
=> 1437         pubmed,uniprot=display_interaction(pdbid,asym_id,bs,title)
   1438     else:
   1439         if lig3:
pubmed = '', uniprot = '', display_interaction = <function display_interaction>, pdbid = '6mcb', asym_id = 'A', bs = 'BS01', title = 'Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.'
 /var/www/html/BioLiP/pdb.cgi in display_interaction(pdbid='6mcb', asym_id='A', bs='BS01', title='Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.')
   1295         display_ec(ec,csaOrig,csaRenu)
   1296     if go:
=> 1297         display_go(go,uniprot,pdbid,asym_id)
   1298     return pubmed,uniprot
   1299 
global display_go = <function display_go>, go = '0003676,0004519', uniprot = '', pdbid = '6mcb', asym_id = 'A'
 /var/www/html/BioLiP/pdb.cgi in display_go(go='0003676,0004519', uniprot='', pdbid='6mcb', asym_id='A')
    480         '''.replace("$namespace_link",namespace_link
    481           ).replace("$namespace",namespace
=>  482           ).replace("$uniprot",u
    483         ))
    484         for l,(term,name) in enumerate(go2aspect[Aspect]):
u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>