Structure of PDB 6mak Chain A Binding Site BS01

Receptor Information
>6mak Chain A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHM
AKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLY
YDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQG
YGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQ
GKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWI
AKEAKRSNSNKTMDPSCLKWTP
Ligand information
>6mak Chain B (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GMVEIEIEGRLHRISIFDPLEIILEDD
Receptor-Ligand Complex Structure
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PDB6mak HBO1 is required for the maintenance of leukaemia stem cells.
Resolution2.13 Å
Binding residue
(original residue number in PDB)		F534 K537 E538 I539 S540 I541 K542 Q560 L565 Y567 H572 L573 V574 L575 K576
Binding residue
(residue number reindexed from 1)		F199 K202 E203 I204 S205 I206 K207 Q225 L230 Y232 H237 L238 V239 L240 K241
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6mak, PDBe:6mak, PDBj:6mak
PDBsum6mak
PubMed31827282
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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