Structure of PDB 6maj Chain A Binding Site BS01

Receptor Information
>6maj Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRH
MAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTL
YYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQ
GYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNF
QGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEW
IAKENKTMDPSCLKWTP
Ligand information
>6maj Chain B (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GMVEIELHRISIFDPLEIIL
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6maj HBO1 is required for the maintenance of leukaemia stem cells.
Resolution2.139 Å
Binding residue
(original residue number in PDB)		F534 K537 E538 I539 S540 I541 K542 H572 L573 V574 K576
Binding residue
(residue number reindexed from 1)		F200 K203 E204 I205 S206 I207 K208 H238 L239 V240 K242
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6maj, PDBe:6maj, PDBj:6maj
PDBsum6maj
PubMed31827282
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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