Structure of PDB 6m94 Chain A Binding Site BS01
Receptor Information
>6m94 Chain A (length=402) Species:
9606
(Homo sapiens) [
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SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDIETI
ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNT
LECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHH
CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV
DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSG
SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD
LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF
LN
Ligand information
>6m94 Chain C (length=9) Species:
9606
(Homo sapiens) [
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YLDSGIHSG
Receptor-Ligand Complex Structure
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PDB
6m94
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
Y271 R285 S309 L311 S325 L351 N394 R474 Y488 R521 F523
Binding residue
(residue number reindexed from 1)
Y125 R139 S163 L165 S179 L205 N248 R328 Y342 R375 F377
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6m94
,
PDBe:6m94
,
PDBj:6m94
PDBsum
6m94
PubMed
30926793
UniProt
Q9Y297
|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)
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