Structure of PDB 6m93 Chain A Binding Site BS01
Receptor Information
>6m93 Chain A (length=402) Species:
9606
(Homo sapiens) [
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SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFKPPNSFYRALYPKIIQDIET
IESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKN
TLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH
HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV
VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVS
GSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVW
DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD
FL
Ligand information
>6m93 Chain C (length=11) Species:
9606
(Homo sapiens) [
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YLDSGIHSGAT
Receptor-Ligand Complex Structure
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PDB
6m93
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
Y271 R285 S309 S325 L351 A391 N394 R474 Y488 R521 F523
Binding residue
(residue number reindexed from 1)
Y126 R140 S164 S180 L206 A246 N249 R329 Y343 R376 F378
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6m93
,
PDBe:6m93
,
PDBj:6m93
PDBsum
6m93
PubMed
30926793
UniProt
Q9Y297
|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)
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