Structure of PDB 6m91 Chain A Binding Site BS01
Receptor Information
>6m91 Chain A (length=402) Species:
9606
(Homo sapiens) [
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SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDIETI
ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNT
LECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHH
CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV
DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSG
SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD
LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF
LN
Ligand information
>6m91 Chain C (length=10) Species:
9606
(Homo sapiens) [
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SYLDSGIHAG
Receptor-Ligand Complex Structure
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PDB
6m91
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
Y271 R285 S309 L311 S325 L351 K365 A392 N394 G408 R474 Y488 F523
Binding residue
(residue number reindexed from 1)
Y125 R139 S163 L165 S179 L205 K219 A246 N248 G262 R328 Y342 F377
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6m91
,
PDBe:6m91
,
PDBj:6m91
PDBsum
6m91
PubMed
30926793
UniProt
Q9Y297
|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)
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