Structure of PDB 6m7u Chain A Binding Site BS01

Receptor Information
>6m7u Chain A (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRF
AVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGVQK
EGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCS
AGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLG
ASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPR
QLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVA
TQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQT
EWSPPLTMLFLCATKFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m7u Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		S113 E116 K224 S257 G259 G260 K261 L262 R382
Binding residue
(residue number reindexed from 1)		S107 E110 K211 S244 G246 G247 K248 L249 R369
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6m7u, PDBe:6m7u, PDBj:6m7u
PDBsum6m7u
PubMed30275308
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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