Structure of PDB 6m1i Chain A Binding Site BS01

Receptor Information
>6m1i Chain A (length=353) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDKIFKKEQAMCLEKIQRAPGCPGMWDNITCWKPAHVGEMVLVSCPELFR
IFNPDQDMGVVSRNCTGWSEPFPHYFDACGFDEGDQDYYYLSVKALYTVG
YSLSLVALLLAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWIL
YAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFF
PERRYFYWYTIIGWGAPLVFVTVWATLRLYFDDTGCWDMNDSTALWWVIK
GPVVGSIMVNFVLFIGIIVILVQKLQSPDSIYLRLARSTLLLIPLFGIHY
TVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWR
SWK
Ligand information
>6m1i Chain B (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HSDGIFTDSYSRYRKQMAVKKYLAAVL
Receptor-Ligand Complex Structure
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PDB6m1i Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D23 F27 I61 I83 F84 D147 Y150 Y157 R199 L210 D215 C219 V237 D298 M299 D301 W306 L382 L386
Binding residue
(residue number reindexed from 1)		D1 F5 I29 I51 F52 D87 Y90 Y97 R139 L150 D155 C159 V177 D238 M239 D241 W246 L316 L320
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m1i, PDBe:6m1i, PDBj:6m1i
PDBsum6m1i
PubMed32047270
UniProtP41586|PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (Gene Name=ADCYAP1R1)

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