Structure of PDB 6lxd Chain A Binding Site BS01

Receptor Information
>6lxd Chain A (length=918) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEK
AKAARPPWIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTG
IRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDD
HEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLE
LFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEV
LSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPG
TKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKS
YVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQG
FWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLA
MTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLI
NIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGL
ATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFQA
LIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQ
LIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRM
EFLGDSIMQLVATEYLFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGM
QEYAITNDKTKRPVALRTKTLADLLQSFIAALYIDKDLEYVHTFMNVCFF
PRLKEFILNQDWNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHAR
TYTVAVYFKGERIGCGKGPSIQQAEMGAAMDALEKYNFPQMAHQKRFIER
KYRQELKEMRWEREHQER
Ligand information
>6lxd Chain B (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PNLHILSKLQEEMKRLAEEREETR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lxd Structural Basis for pri-miRNA Recognition by Drosha.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		L987 Y999 Q1005 L1074 V1077 W1078
Binding residue
(residue number reindexed from 1)		L541 Y553 Q559 L628 V631 W632
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6lxd, PDBe:6lxd, PDBj:6lxd
PDBsum6lxd
PubMed32220645
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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