Structure of PDB 6lwm Chain A Binding Site BS01

Receptor Information
>6lwm Chain A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QNPDLLELCHSVPKEVVQLGGKGYEEDFAAFRAWLRCYGMPGMSSLQDRH
GRTIWFQGDPGPLAP
Ligand information
Receptor-Ligand Complex Structure
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PDB6lwm DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
Resolution2.67 Å
Binding residue
(original residue number in PDB)		P2 E3 E6 K54 G80 M81 R118 F120 R133 Q168 N176 Y263 R277
Binding residue
(residue number reindexed from 1)		P1 E2 E5 K53 G79 M80 R117 F119 R132 Q167 N175 Y238 R252
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwm, PDBe:6lwm, PDBj:6lwm
PDBsum6lwm
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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