Structure of PDB 6lse Chain A Binding Site BS01

Receptor Information
>6lse Chain A (length=464) Species: 39054 (Enterovirus A71) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLYEPDEYIKEAALHYANQLKQLDIDTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDSTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLVEGINHTHHVYRNKTYCVLGGMPSGMSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELARTGKE
YGLTMTPADKSPCFNEVNWDNATFLKRGFLPDEQFPFLIHPTMPMKEIHE
SIRWTKDARNTQDHVRSLCLLAWHNGKQEYEKFVSAIRSVPVGKALAIPN
YENLRRNWLELFHH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lse Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		P20 E108 T114 S115 S121 K127 Y157 I176 A178 R188 H199 G211 C212 N213 G290 M291 S292 Y327
Binding residue
(residue number reindexed from 1)		P20 E108 T114 S115 S121 K127 Y157 I176 A178 R188 H199 G211 C212 N213 G290 M291 S292 Y327
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6lse, PDBe:6lse, PDBj:6lse
PDBsum6lse
PubMed32451382
UniProtE5RPG3

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