Structure of PDB 6lry Chain A Binding Site BS01

Receptor Information
>6lry Chain A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLYIIYKNKCMRNG
PNILIASLALGDLLHIVIAIPINVYKLLAEDWPFGAEMCKLVPFIQKASV
GITVLSLCALSIDRYRAVASWSRIKVPKWTAVEIVLIWVVSVVLAVPEAI
GFDIITMDYKGSYLRICLLHPVQKTAFMQFYATAKDWWLFSFYFCLPLAI
TAFFYTLMTCEMLRKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKS
PSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKP
VYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKS
RWYNQTPNRAKRVITTFRTGTWDAYLNDHLKQRREVAKTVFCLVLVFALC
WLPLHLARILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCANPIA
LYLVSKRFKNAFKSALCC
Ligand information
>6lry Chain B (length=21) Species: 1343144 (Atractaspis engaddensis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CSCKDMTDKECLYFCHQDVIW
Receptor-Ligand Complex Structure
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PDB6lry Crystal structure of human endothelin ETBreceptor in complex with sarafotoxin S6b.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		P87 I94 N158 K161 E165 V177 Q181 K182 M245 Y247 K248 L252 I254 L256 L257 P259 K273 W336 L339 R343 K346 Y350 R357 L361 L364 L365 D368 Y369
Binding residue
(residue number reindexed from 1)		P2 I9 N73 K76 E80 V92 Q96 K97 M157 Y159 K160 L164 I166 L168 L169 P171 K185 W401 L404 R408 K411 Y415 R422 L426 L429 L430 D433 Y434
Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lry, PDBe:6lry, PDBj:6lry
PDBsum6lry
PubMed32001000
UniProtP24530|EDNRB_HUMAN Endothelin receptor type B (Gene Name=EDNRB)

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