Structure of PDB 6loz Chain A Binding Site BS01

Receptor Information
>6loz Chain A (length=245) Species: 3673 (Momordica charantia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVSFRLSGADPRSYGMFIKDLRNALPFREKVYNIPLLLPSVSGAGRYLLM
HLFNYDGKTITVAVDVTNVYIMGYLADTTSYFFNEPAAELASQYVFRDAR
RKITLPYSGNYERLQIAAGKPREKIPIGLPALDSAISTLLHYDSTAAAGA
LLVLIQTTAEAARFKYIEQQIQERAYRDEVPSLATISLENSWSGLSKQIQ
LAQGNNGIFRTPIVLVDNKGNRVQITNVTSKVVTSNIQLLLNTRN
Ligand information
Ligand IDADE
InChIInChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
InChIKeyGFFGJBXGBJISGV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ncnc2[nH]cnc12
OpenEye OEToolkits 1.5.0c1[nH]c2c(n1)c(ncn2)N
ACDLabs 10.04n1c(c2ncnc2nc1)N
FormulaC5 H5 N5
NameADENINE
ChEMBLCHEMBL226345
DrugBankDB00173
ZINCZINC000000000882
PDB chain6loz Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6loz Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs.
Resolution1.08 Å
Binding residue
(original residue number in PDB)		Y93 I94 G132 Y134 I178 R186
Binding residue
(residue number reindexed from 1)		Y70 I71 G109 Y111 I155 R163
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:6loz, PDBe:6loz, PDBj:6loz
PDBsum6loz
PubMed32653369
UniProtP16094|RIP1_MOMCH Ribosome-inactivating protein momordin I

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