Structure of PDB 6ld5 Chain A Binding Site BS01

Receptor Information
>6ld5 Chain A (length=575) Species: 2043570 (Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEAPNMKIIGNRIERIRSEHAETWFFDENHPYRTWAYHGSYEAPLINGVV
RLLSKPWDVVTGVTGIAPYGQQRVFKEKVDTRVPDPQEGTRQVMSMVSSW
LWKELGKHKRPRVCTKEEFINKVRSVNDPRFWALVDKEREHHLRGECQSC
VYNMMGKRESRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLG
LQRLGYVLEEMSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGH
RALALAIIKYTYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALN
TFTNLVVQLIRNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAV
SGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCS
HHFNKLHLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQ
MWQLLYFHRRDLRLMANAICSSVPVDWVPTGRTTWSIHGKGEWMTTEDML
VVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWA
ENIKNTVNMVRRIIGDEEKYMDYLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ld5 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ld5 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.
Resolution1.94 Å
Binding residue
(original residue number in PDB)		E439 H443 C448 C451
Binding residue
(residue number reindexed from 1)		E138 H142 C147 C150
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6ld5, PDBe:6ld5, PDBj:6ld5
PDBsum6ld5
PubMed32796069
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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