Structure of PDB 6l7w Chain A Binding Site BS01

Receptor Information
>6l7w Chain A (length=185) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAEQRAVAKALFDAVNKHLSNPFIEVEMRLGQFFTACVSTEDYERIKTYL
MTEMENSSMTRSVTHDVSLRGWRHTYATDENGNPTRCVSIVRKKRLFVKN
IVVPLGAYNLRFAVSTETPGHTRLKDRLSITDGMFRYDMTQVTEKGVLMH
EVEIEGVFSSHEKQLTESWLEELLRRAMRLATLRT
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6l7w Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6l7w Crystal structures of the RNA triphosphatase fromTrypanosoma cruziprovide insights into how it recognizes the 5'-end of the RNA substrate.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E42 E44 E212
Binding residue
(residue number reindexed from 1)		E25 E27 E155
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0004651 polynucleotide 5'-phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:6l7w, PDBe:6l7w, PDBj:6l7w
PDBsum6l7w
PubMed32381506
UniProtQ4E2I1

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