Structure of PDB 6l6r Chain A Binding Site BS01

Receptor Information
>6l6r Chain A (length=610) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADPLLLYANRRDLRLVDATNENATIVVGGLEDAAAVDFVFSHGLIYWSDV
SEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDG
SSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVV
KGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENG
KTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPV
EGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPK
IERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTD
GTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIID
QLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFEL
ISDMKTCIVP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6l6r Chain A Residue 1007 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6l6r Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		N117 D138 Q139
Binding residue
(residue number reindexed from 1)		N97 D118 Q119
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6l6r, PDBe:6l6r, PDBj:6l6r
PDBsum6l6r
PubMed33097721
UniProtO75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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