Structure of PDB 6l63 Chain A Binding Site BS01

Receptor Information
>6l63 Chain A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPED
LTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDAD
GSCALLSPYVQPVCLPSGLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLE
RCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCELTLQGIISWG
SGCGDRNKPGVYTDVAYYLAWIREHTVS
Ligand information
>6l63 Chain B (length=18) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YFAYDRRKLSNNKRNYCG
Receptor-Ligand Complex Structure
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PDB6l63 Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic beta-amino acids.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		W392 S395 H412 Y458 Y515 H538 S541 D557 A558 C559 Q560 G561 S563 S585 W586 G587 S588
Binding residue
(residue number reindexed from 1)		W20 S23 H40 Y86 Y135 H158 S161 D177 A178 C179 Q180 G181 S183 S198 W199 G200 S201
Enzymatic activity
Catalytic site (original residue number in PDB) H412 D461 Q560 G561 D562 S563
Catalytic site (residue number reindexed from 1) H40 D89 Q180 G181 D182 S183
Enzyme Commision number 3.4.21.38: coagulation factor XIIa.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6l63, PDBe:6l63, PDBj:6l63
PDBsum6l63
PubMed32839601
UniProtP00748|FA12_HUMAN Coagulation factor XII (Gene Name=F12)

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