Structure of PDB 6l5n Chain A Binding Site BS01

Receptor Information
>6l5n Chain A (length=377) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGK
TFSFAIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKK
LSVACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHV
VLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVA
KKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIRVYSG
HQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITLKGFRNG
SFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGV
CICFYQHKEEYQLVQVEQKAGIKFKRI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6l5n Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Resolution2.242 Å
Binding residue
(original residue number in PDB)		P268 T269 R270 G294 G295 Y298 T315 G317 R318 D321 F349 Q352 E446 K448 H468 G469 R476 T494
Binding residue
(residue number reindexed from 1)		P82 T83 R84 G108 G109 Y112 T129 G131 R132 D135 F163 Q166 E260 K262 H282 G283 R290 T308
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6l5n, PDBe:6l5n, PDBj:6l5n
PDBsum6l5n
PubMed32714761
UniProtQ9NR30|DDX21_HUMAN Nucleolar RNA helicase 2 (Gene Name=DDX21)

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