Structure of PDB 6l1p Chain A Binding Site BS01

Receptor Information
>6l1p Chain A (length=68) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMPPNRPGITFEIGARLEALDYLQKWYPSRIEKIDYEEGKMLVHFERWSH
RYDEWIYWDSNRLRPLER
Ligand information
Ligand IDE3X
InChIInChI=1S/C12H15NO/c1-13-8-6-11(7-9-13)10-2-4-12(14)5-3-10/h2-6,14H,7-9H2,1H3
InChIKeyGIGCUVKCMPXMAZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CN1CCC(=CC1)c2ccc(cc2)O
CACTVS 3.385CN1CCC(=CC1)c2ccc(O)cc2
FormulaC12 H15 N O
Name4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenol
ChEMBLCHEMBL108967
DrugBank
ZINCZINC000001706757
PDB chain6l1p Chain A Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6l1p Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
Resolution1.231 Å
Binding residue
(original residue number in PDB)		D23 Y24 L25 Y29 F47 W50 Y54
Binding residue
(residue number reindexed from 1)		D21 Y22 L23 Y27 F45 W48 Y52
Annotation score1
Binding affinityMOAD: Kd=0.31mM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6l1p, PDBe:6l1p, PDBj:6l1p
PDBsum6l1p
PubMed32885980
UniProtA8MW92|P20L1_HUMAN PHD finger protein 20-like protein 1 (Gene Name=PHF20L1)

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