Structure of PDB 6l03 Chain A Binding Site BS01

Receptor Information
>6l03 Chain A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPG
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQ
GPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPAYGVPSS
AASLIDFLRVVRNQQSLAVSNMPEPPIVVHASAGIGRTGTFCSLDICLAQ
LEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6l03 PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Resolution2.084 Å
Binding residue
(original residue number in PDB)		Y333 D335 Y471 A515 S516 A517 I519 G520 R521 Q559
Binding residue
(residue number reindexed from 1)		Y57 D59 Y195 A231 S232 A233 I235 G236 R237 Q275
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6l03, PDBe:6l03, PDBj:6l03
PDBsum6l03
PubMed33764618
UniProtP43378|PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (Gene Name=PTPN9)

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