Structure of PDB 6kzq Chain A Binding Site BS01

Receptor Information
>6kzq Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPG
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQ
GPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPAYGVPSS
AASLIDFLRVVRNQQSLAVSNMEPPIVVHASAGIGRTGTFCSLDICLAQL
EELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kzq PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		Y333 D335 Y471 A515 S516 A517 I519 G520 R521 Q559
Binding residue
(residue number reindexed from 1)		Y57 D59 Y195 A230 S231 A232 I234 G235 R236 Q274
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6kzq, PDBe:6kzq, PDBj:6kzq
PDBsum6kzq
PubMed33764618
UniProtP43378|PTN9_HUMAN Tyrosine-protein phosphatase non-receptor type 9 (Gene Name=PTPN9)

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