Structure of PDB 6kzp Chain A Binding Site BS01

Receptor Information
>6kzp Chain A (length=1014) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFA
VEMVVKMVAGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLR
AINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN
RCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLR
CVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYF
VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREIVDSKYF
GRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLL
VYGPFGYIKNPYNIFDGVIVVISVWEIVSVLRTFRLMRVLKLVRFLPALQ
RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASLPDRKNFDS
LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNL
LVAILVEGFQFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS
AERIFLTLSNYIFTAVFLAEMTVKVVALGSSWNVLDGLLVLISVIDILVS
MVSKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVI
CCAFFIIFGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYN
FDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFI
SFLLIVAFFVLNMFVGVVVENFHYLDLFITGVIGLNVVTMAMEHYQQPQI
LDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSIM
GITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQ
ALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNF
GMAFLTLFRVSTGDNWNGIMKDTLRDYNTVISPIYFVSFVLTAQFVLVNV
VIAVLMKHLEESNK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6kzp Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kzp Cryo-EM structures of apo and antagonist-bound human Cav3.1.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E354 E923 D1463
Binding residue
(residue number reindexed from 1)		E242 E465 D718
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005261 monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kzp, PDBe:6kzp, PDBj:6kzp
PDBsum6kzp
PubMed31766050
UniProtO43497|CAC1G_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1G (Gene Name=CACNA1G)

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