Structure of PDB 6kxy Chain A Binding Site BS01

Receptor Information

>6kxy Chain A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLAKRIYEAYLKNFNMNKVKARVILSGKNPPFVIHDMETLCMAEKTLVAQ
NKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVY
EAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMK
FNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQS
NHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIY
RDM

Ligand information

>6kxy Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PSLLKKLLLAP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6kxy Structural Basis for PPAR alpha Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	K292 L302 N303 Q305 V306 L309 P458 L459 E462
Binding residue (residue number reindexed from 1)	K78 L88 N89 Q91 V92 L95 P244 L245 E248

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6kxy, PDBe:6kxy, PDBj:6kxy
PDBsum	6kxy
PubMed	32376995
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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