Structure of PDB 6kwr Chain A Binding Site BS01

Receptor Information

>6kwr Chain A (length=453) Species: 39054 (Enterovirus A71)

GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDIFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLHEPDEYIKEAALHYANQLKQLEINTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDPTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMAFGHLYEAFHA
NPGTITGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPVNWGNATFLKRGFLPDEQFPFLIHPTMPMREIHESIRWTKDAR
NTQDHVRSLCLLAWHNGKQEYEKFVSTIRSVPVGRALAIPNYENLRRNWL
ELF

Ligand information

>6kwr Chain B (length=28)

gggagaugagucuccaggucucucggaa

.<<<<<<..>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6kwr A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): N18 P20 K24 S45 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 R277 S289 G290 C291 S292 Y327 R416 L420
• Binding residue (residue number reindexed from 1): N18 P20 K24 S45 E108 T114 S115 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 R277 S289 G290 C291 S292 Y327 R407 L411

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.29: picornain 2A.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6kwr, PDBe:6kwr, PDBj:6kwr
• PDBsum: 6kwr
• PubMed: 31863580
• UniProt: M4QLY4