Structure of PDB 6kun Chain A Binding Site BS01

Receptor Information
>6kun Chain A (length=294) Species: 39946 (Oryza sativa Indica Group) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIPAIDLRLAGGGGGAEETARLRDACARLGCFRVSGHGVPPGLQAEMKAA
VRALFDLPDDAKRRNADIIPGSGYVPPPLYEAFGLCDAAAPADVDAFCAR
LDAPPHVRETVKAYAERMHSLIVDVAGKVAASLGLHGASFQDWPCQFRMN
RYNYTQDSVGSPGVQVHTDSGFLTVLQEDECVGGLEVLDPAAGEFVPVDP
LPGSFVVNVGDVGQAWSNGRLHNVKHRVQCVAAVPRVSIAMFLLAPKDDT
VSAPGELVDGEHPRRYREFKYDDYRRLRLSTGERAGEALARLAA
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain6kun Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kun A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin.
Resolution2.002 Å
Binding residue
(original residue number in PDB)		Y158 H173 D175 H232 R242 S244
Binding residue
(residue number reindexed from 1)		Y152 H167 D169 H226 R236 S238
Annotation score4
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0009852 auxin catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6kun, PDBe:6kun, PDBj:6kun
PDBsum6kun
PubMed32358569
UniProtQ01IX6|DAO_ORYSI 2-oxoglutarate-dependent dioxygenase DAO (Gene Name=DAO)

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