Structure of PDB 6kr6 Chain A Binding Site BS01

Receptor Information
>6kr6 Chain A (length=713) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSNHANLL
GSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPR
FLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIR
QHEKDILLGTEITHKVMRTETIYDIMRRCSDEVRVNVLDLIVLTDYNNRT
YRINDVDFGQTPKSTFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISVVL
IPELCRVNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDW
NMELDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPS
DGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTG
TYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLK
TTKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDR
KRAYGALIASMDLQQNSTYFSTVTECANTLWPMIAKALRQYQHEHRKLPS
RIVFYRDGVGSLKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSM
NTRFFLNGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLY
SSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLHS
IPQNALEKKFYYL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6kr6 Crystal structure of Drosophila Piwi.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		A548 Y551 K555 Q567 V568 T570 T573 I586 Q589 N803 W804 L843
Binding residue
(residue number reindexed from 1)		A426 Y429 K433 Q445 V446 T448 T451 I464 Q467 N673 W674 L713
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0034584 piRNA binding
GO:0046872 metal ion binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0007279 pole cell formation
GO:0007283 spermatogenesis
GO:0007294 germarium-derived oocyte fate determination
GO:0010526 retrotransposon silencing
GO:0016441 post-transcriptional gene silencing
GO:0030718 germ-line stem cell population maintenance
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031507 heterochromatin formation
GO:0034587 piRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0048132 female germ-line stem cell asymmetric division
GO:0048133 male germ-line stem cell asymmetric division
GO:0048477 oogenesis
GO:0090309 positive regulation of DNA methylation-dependent heterochromatin formation
GO:0140990 primary piRNA processing
GO:0140991 piRNA-mediated gene silencing by mRNA destabilization
GO:0141005 retrotransposon silencing by heterochromatin formation
GO:0141006 piRNA-mediated retrotransposon silencing by heterochromatin formation
Cellular Component
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010369 chromocenter
GO:0032991 protein-containing complex
GO:0043073 germ cell nucleus
GO:0043186 P granule
GO:0070725 Yb body
GO:0090571 RNA polymerase II transcription repressor complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6kr6, PDBe:6kr6, PDBj:6kr6
PDBsum6kr6
PubMed32051406
UniProtQ9VKM1|PIWI_DROME Protein piwi (Gene Name=piwi)

[Back to BioLiP]