Structure of PDB 6kls Chain A Binding Site BS01

Receptor Information

>6kls Chain A (length=134) Species: 224324 (Aquifex aeolicus VF5)

FISIGIGALGAVGGLGALYALVRVMLEPSEIAALGAKTEIDVSKIQPMQV
RVTSWKGKTLFAIRLPKDYEILKGHDVFALVGVCTHLGCIPLWKPVFHCP
CHGGLYTPYGDVIGGPPPRPLFIPPQKLEGNKLI

Ligand information

• Ligand ID: FES
• InChI: InChI=1S/2Fe.2S
• InChIKey: NIXDOXVAJZFRNF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04: [Fe]1S[Fe]S1
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: S1[Fe]S[Fe]1
• Formula: Fe2 S2
• Name: FE2/S2 (INORGANIC) CLUSTER
• PDB chain: 6kls Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6kls A 3.3 angstrom -Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of Its Thermal Stability.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): C111 H113 L114 C116 C135 H138
• Binding residue (residue number reindexed from 1): C84 H86 L87 C89 C99 H102
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H138
• Catalytic site (residue number reindexed from 1): H102

Gene Ontology

Molecular Function

• GO:0008121 ubiquinol-cytochrome-c reductase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6kls, PDBe:6kls, PDBj:6kls
• PDBsum: 6kls
• PubMed: 31778296
• UniProt: O66460