Structure of PDB 6kle Chain A Binding Site BS01

Receptor Information
>6kle Chain A (length=1592) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTEQVESFNEIKHDVQVALAKMADVSLHEVKDFDPDVLP
PEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLKNLTTSSYVDEEYFM
CFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSISSNSGNLKFGLSYK
EQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFERAIC
DMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKIDLD
SVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFFHQTMQLNGQIPSHI
MSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQITL
IKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFVMGE
ETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTRISK
RVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDDKET
SFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSEQEV
NRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQSKLSRQSSVASGFI
GFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSLNKV
SQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNNQNFFWAVKPKVVRQ
IEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFLDVC
IALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kle Structural insight into arenavirus replication machinery.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		N335 K336 N390 D391 S492 L495 K502 T503 S504 F533 Y534 Y867 Y1449 K1623 S1627
Binding residue
(residue number reindexed from 1)		N308 K309 N363 D364 S459 L462 K469 T470 S471 F494 Y495 Y806 Y1258 K1404 S1408
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6kle, PDBe:6kle, PDBj:6kle
PDBsum6kle
PubMed32214249
UniProtQ6IVU0

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