Structure of PDB 6kf9 Chain A Binding Site BS01

Receptor Information
>6kf9 Chain A (length=900) Species: 69014 (Thermococcus kodakarensis KOD1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVIGSIEFGILSPQEIRKMSAAEITVPDTYDDDGYPIEGGLMDKRLGVI
DPGLRCETCGARAGECPGHFGHIELARPVIHVGFAKTIHRVLESTCRECG
RIKLTDEEIEEYMQKFEVMGDRKGAVDKLIKEIHKKAKERMVCPHCGAPQ
FPIKFERPTIYWELRKDEEGNEYKHRMMPSEVRDRLEKIPDKDLPLLGLH
PEKSRPEWMVLTVLPVPPVTMRPSITLESGIRAEDDLTHKLVDIIRINNR
LKSNIEAGAPQLIIEDLWDLLQYHVTTYINNETSGVPPAKHKSGRPLKTL
AQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPLAVAMELT
VPEKVTEFNYEKLKQRVLNGPEKYPGANYVIDPEGRRIRLMESNRELIAE
KLDIGWTVERHLEDGDVVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLPV
CPPYNADFDGDEMNLHVPQTEEAQAEAKILMEVQNHIISPRYGGPLIAGI
QDHISGGYLLTREGAYFTRYEVEQMLMFAGMDVNELPEPDKYENGEPLWS
GKTIFSLLLPDDLTIWYRNKLCDEPERCEALEKLIEEKLIPDPEEVRKLA
YDGFVYIQNGKLLSGAVDKKAYGREDGKLLDIIVREYGVERARQFLDQVT
KLTIWVITHKGFTTAIDDEDLPQEAIDRIHEIIREAEEKVQRLIEAYKRG
ELEPLPGKTLEETLESKIMAVLAEARDNAGKVAERYLGMNNHAVIMAKTG
ARGKILNITQMAAMLGQQSIRGKRLYRGYRGRVLTHFKPGDLGARARGFV
TNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDLKV
DYDGTVRDPTGIIVQFKYGEDGVDPMKSWQGKTVDVDRVIVRTLLKMRGG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kf9 Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Resolution3.79 Å
Binding residue
(original residue number in PDB)		Q427 T835 Y840
Binding residue
(residue number reindexed from 1)		Q423 T831 Y836
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kf9, PDBe:6kf9, PDBj:6kf9
PDBsum6kf9
PubMed33257704
UniProtQ5JE33

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