Structure of PDB 6kds Chain A Binding Site BS01

Receptor Information
>6kds Chain A (length=221) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQKFLRK
FVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQN
YLQVKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSR
CRDGLKENGIIILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVL
GQEKQDGFPEQCIPVWMFALH
Ligand information
Receptor-Ligand Complex Structure
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PDB6kds Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2
Resolution1.844 Å
Binding residue
(original residue number in PDB)		M87 F90 W191 N223 R226 Q268 C269 I270
Binding residue
(residue number reindexed from 1)		M30 F33 W134 N166 R169 Q211 C212 I213
Enzymatic activity
Enzyme Commision number 2.1.1.299: protein N-terminal monomethyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0006480 N-terminal protein amino acid methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6kds, PDBe:6kds, PDBj:6kds
PDBsum6kds
PubMed
UniProtQ5VVY1|NTM1B_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 2 (Gene Name=NTMT2)

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