Structure of PDB 6k8o Chain A Binding Site BS01

Receptor Information
>6k8o Chain A (length=665) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSK
YVIVPAAGHLFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLS
KYALGFINACDYDIEGSVIGYLIIKNLGDIKKAKRMKFSALTKSDILSAF
RNISALDYDMINAGIARHKIDWLWGINVSRALMISLQDFAKKRVILSAGR
VQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLNIKVNKEFEKIT
EAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISPY
NVERIAEDLYLDGLISFPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLV
RKITGGKYVVKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLG
SVSADAKLSNTIYTLKVSDFPLEFTVSYTKILERNWLDIYHFHNVKEDKP
IFLSKGDEGKIVDGKVNISLSKPTSRYTKVSLLKWMESSNLGTEATRGRI
IEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVDVRMTADMESKL
EMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIVK
CKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSK
STGKYVKDIVTYMLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6k8o Crystal structures of the Sulfolobus solfataricus topoisomerase III reveal that its C-terminal novel zinc finger part is a unique decatenation domain
Resolution2.5 Å
Binding residue
(original residue number in PDB)
E15 K16 A58 G59 H60 Y89 E116 R168 H169 D172 W173 G176 I177 S180 R181 M184 I196 S198 A199 G200 R201 V202 Q203 E308 F318 R320 T494 A496 T497 R500 R508
Binding residue
(residue number reindexed from 1)
E14 K15 A57 G58 H59 Y88 E115 R167 H168 D171 W172 G175 I176 S179 R180 M183 I195 S197 A198 G199 R200 V201 Q202 E307 F317 R319 T493 A495 T496 R499 R507
Enzymatic activity
Catalytic site (original residue number in PDB) E15 K16 D112 D114 F318 R320
Catalytic site (residue number reindexed from 1) E14 K15 D111 D113 F317 R319
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0046872 metal ion binding
Biological Process
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006310 DNA recombination

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Molecular Function

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Biological Process
External links
PDB RCSB:6k8o, PDBe:6k8o, PDBj:6k8o
PDBsum6k8o
PubMed
UniProtQ97ZJ8

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