Structure of PDB 6k1z Chain A Binding Site BS01

Receptor Information
>6k1z Chain A (length=544) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYL
MNKLAGKHTKGIWMWCVPHPKKPGHILVLLDTEGLGDNQNDSWIFALAVL
LSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPEVEDSADFVSFFP
DFVWTLRDFSLDLPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFP
KKKCFVFDRPDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVL
TYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTE
TLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQ
NQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYY
EEPRKGIQAEEILQTYLKSKESMTDAILQTDQTLTEKEKEIEVERVKAES
AQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQER
TLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain6k1z Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6k1z Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8.
Resolution2.307 Å
Binding residue
(original residue number in PDB)		A385 Y524 H527 L528 C589 I591
Binding residue
(residue number reindexed from 1)		A337 Y476 H479 L480 C541 I543
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.5.-
Gene Ontology
Molecular Function
GO:0001530 lipopolysaccharide binding
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0004382 GDP phosphatase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0019899 enzyme binding
GO:0019955 cytokine binding
GO:0030507 spectrin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051879 Hsp90 protein binding
Biological Process
GO:0032703 negative regulation of interleukin-2 production
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0045087 innate immune response
GO:0050848 regulation of calcium-mediated signaling
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051607 defense response to virus
GO:0051715 cytolysis in another organism
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to type II interferon
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0072665 protein localization to vacuole
GO:0140639 positive regulation of pyroptotic inflammatory response
GO:0160075 non-canonical inflammasome complex assembly
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1903076 regulation of protein localization to plasma membrane
GO:1903077 negative regulation of protein localization to plasma membrane
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0106139 symbiont cell surface

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k1z, PDBe:6k1z, PDBj:6k1z
PDBsum6k1z
PubMed31216343
UniProtP32455|GBP1_HUMAN Guanylate-binding protein 1 (Gene Name=GBP1)

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