Structure of PDB 6jxk Chain A Binding Site BS01

Receptor Information
>6jxk Chain A (length=987) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTP
EYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALI
AVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVV
GDLVEMKGGDRVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPL
ETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIE
IEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLL
ATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT
VSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQ
DAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNK
FQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREA
FQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLCFAG
LVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEG
SETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPE
MVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIA
GSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPEL
TPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPR
NPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLR
PQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIR
KTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQ
WWLVPMPFSLLIFVYDEIRKLGVRCCPGSWWDQELYY
Ligand information
Ligand IDMF4
InChIInChI=1S/4FH.Mg/h4*1H;/q;;;;+2/p-4
InChIKeyXVYWAXYEHHUKQW-UHFFFAOYSA-J
SMILES
SoftwareSMILES
CACTVS 3.341F[Mg--](F)(F)F
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		F[Mg-2](F)(F)F
FormulaF4 Mg
NameTETRAFLUOROMAGNESATE(2-);
MAGNESIUMTETRAFLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain6jxk Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6jxk A single K + -binding site in the crystal structure of the gastric proton pump.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		T228 G229 D385 K386 T387 T626 G627 K707 N729
Binding residue
(residue number reindexed from 1)		T182 G183 D339 K340 T341 T580 G581 K661 N683
Annotation score1
Enzymatic activity
Enzyme Commision number 7.2.2.19: H(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jxk, PDBe:6jxk, PDBj:6jxk
PDBsum6jxk
PubMed31436534
UniProtP19156|ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (Gene Name=ATP4A)

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