Structure of PDB 6juo Chain A Binding Site BS01

Receptor Information
>6juo Chain A (length=347) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTKWVLHVDLDQFYASVELRRRPDLRGQPVIVGGSGDPSEPRKVVTCASY
EAREFGVHAGMPLRAAARRCPDATFLPSDPAAYDEASEQVMGLLRDLGHP
LEVWGWDEAYLGADLPDESDPVEVAERIRTVVAAETGLSCSVGISDNKQR
AKVATGFAKPAGIYVLTEANWMTVMGDRPPDALWGVGPKTTKKLAAMGIT
TVADLAVTDPSVLTTAFGPSTGLWLLLLAKGGGDTEVSSEPWVPRSRSHV
VTFPQDLTERREMDSAVRDLALQTLAEIVEQGRIVTRVAVTVRTSTFYTR
TKIRKLPAPSTDAGQIVDTALAVLDQFELDRPVRLLGVRLELAMDDV
Ligand information
Receptor-Ligand Complex Structure
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PDB6juo A polar filter in DNA polymerases prevents ribonucleotide incorporation.
Resolution2.16 Å
Binding residue
(original residue number in PDB)		R42 V44 W242 P244 R245 S246 R247 S248 H249 V250 V251 T252 F297 R334
Binding residue
(residue number reindexed from 1)		R42 V44 W242 P244 R245 S246 R247 S248 H249 V250 V251 T252 F297 R334
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0009432 SOS response
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6juo, PDBe:6juo, PDBj:6juo
PDBsum6juo
PubMed31544946
UniProtA0QR77

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