Structure of PDB 6jtz Chain A Binding Site BS01

Receptor Information

>6jtz Chain A (length=303) Species: 9606 (Homo sapiens)

NRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVT
VSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKP
DVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVV
MENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVACNKMCDNCCKDSAFE
RKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAP
TLPREDLEKIIAHFLIQQYLKEDYSAAISYLKIGPKANLLNNEAHAITMQ
VTK

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6jtz Chain A Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6jtz Residues at the interface between zinc binding and winged helix domains of human RECQ1 play a significant role in DNA strand annealing activity.
• Resolution: 2.797 Å
• Binding residue (original residue number in PDB): C453 C471 C475 C478
• Binding residue (residue number reindexed from 1): C172 C186 C190 C193
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

Molecular Function

• GO:0004386 helicase activity
• GO:0043138 3'-5' DNA helicase activity

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair
• GO:0006310 DNA recombination

External links

• PDB: RCSB:6jtz, PDBe:6jtz, PDBj:6jtz
• PDBsum: 6jtz
• PubMed: 34751402
• UniProt: P46063|RECQ1_HUMAN ATP-dependent DNA helicase Q1 (Gene Name=RECQL)