Structure of PDB 6jq7 Chain A Binding Site BS01

Receptor Information
>6jq7 Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB6jq7 Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		K301 L311 Q314 V315 K319 E471
Binding residue
(residue number reindexed from 1)		K84 L94 Q97 V98 K102 E254
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jq7, PDBe:6jq7, PDBj:6jq7
PDBsum6jq7
PubMed31371757
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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