Structure of PDB 6jo3 Chain A Binding Site BS01

Receptor Information
>6jo3 Chain A (length=247) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMTVLEDMLRKTRNGKVHMTLIDPGAKPPQECARIAEEAEMAGTDFIMVG
GSTDIDSRAMDEAISAIKAKTDLKVIIFPGSSLMISPKADAIFFMSLLNS
GSLEYVVGHQVKAAIPLSAMKIEKIPMAYLVFDPGMTVGRVGKAHLIPRD
DEKTALSYALAAQYFGFRLVYFEAGSGSPYHVGENVVRRVKQELDIPVIV
GGGIRTPEAAKALAQAGADMIVTGTIAERSVNVYEALHPIVESIKEV
Ligand information
Ligand ID1GP
InChIInChI=1S/C3H9O6P/c4-1-3(5)2-9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)/t3-/m0/s1
InChIKeyAWUCVROLDVIAJX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H](COP(=O)(O)O)O)O
ACDLabs 10.04O=P(O)(O)OCC(O)CO
CACTVS 3.341OC[CH](O)CO[P](O)(O)=O
CACTVS 3.341OC[C@H](O)CO[P](O)(O)=O
FormulaC3 H9 O6 P
NameSN-GLYCEROL-1-PHOSPHATE
ChEMBL
DrugBank
ZINCZINC000003830895
PDB chain6jo3 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6jo3 Crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase from Thermoplasma acidophilum in complex with the substrate sn-glycerol 1-phosphate.
Resolution2.35 Å
Binding residue
(original residue number in PDB)
L21 Y171 E173 S176 G201 G202 T223 G224 T225
Binding residue
(residue number reindexed from 1)
L21 Y171 E173 S176 G201 G202 T223 G224 T225
Annotation score5
Enzymatic activity
Enzyme Commision number 2.5.1.41: phosphoglycerol geranylgeranyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0002094 polyprenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
GO:0047294 phosphoglycerol geranylgeranyltransferase activity
Biological Process
GO:0006650 glycerophospholipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Cellular Component
External links
PDB RCSB:6jo3, PDBe:6jo3, PDBj:6jo3
PDBsum6jo3
PubMed31282866
UniProtQ9HJH3|GGGPS_THEAC Geranylgeranylglyceryl phosphate synthase (Gene Name=Ta0995)

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