Structure of PDB 6jm9 Chain A Binding Site BS01

Receptor Information
>6jm9 Chain A (length=98) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSS
AVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>6jm9 Chain I (length=123) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cacctgcagattctaccaaaagtgtatttggaaactgctccatcaaaagg
catgttcagctgaattcagctgaacatgccttttgatggagcagtttcca
aatacacttttggtagaatctgc
Receptor-Ligand Complex Structure
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PDB6jm9 Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Resolution7.3 Å
Binding residue
(original residue number in PDB)		R42 R63 R72 R83 F84 Q85 S86 R116 V117 T118
Binding residue
(residue number reindexed from 1)		R5 R26 R35 R46 F47 Q48 S49 R79 V80 T81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6jm9, PDBe:6jm9, PDBj:6jm9
PDBsum6jm9
PubMed30923167
UniProtP84233|H32_XENLA Histone H3.2

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