Structure of PDB 6jlq Chain A Binding Site BS01

Receptor Information
>6jlq Chain A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FGLVNFGNTCYCNSVLQALYFCRPFRENVLALTCLADLFHSIAIPPKKFI
SRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQELTWVHEIFQG
TLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSE
QKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRV
VFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFW
LLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6jlq Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6jlq Structural insights into the activation of USP46 by WDR48 and WDR20.
Resolution3.101 Å
Binding residue
(original residue number in PDB)		C182 C185 C229 C232
Binding residue
(residue number reindexed from 1)		C108 C111 C155 C158
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006508 proteolysis
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jlq, PDBe:6jlq, PDBj:6jlq
PDBsum6jlq
PubMed31632687
UniProtP62068|UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (Gene Name=USP46)

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