Structure of PDB 6jk8 Chain A Binding Site BS01

Receptor Information
>6jk8 Chain A (length=823) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISRSYRFPKLTVITEYL
LLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRN
ITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPCE
KTTINNEYNYRCWTTNRCQKMCPSTCACTENNECCHPECLGSCSAPDNDT
ACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGF
VIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTS
AQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHAL
VSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKM
YFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFT
STTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGS
NSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRG
AKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV
RWQRQPQDGYLYRHNYCSKDKIPIRKYAGPCCACPKTEAEKQAEKEEAEY
RKVFENFLHNSIFVPRPYPFFESRVDNKERTVISNLRPFTLYRIDIHSCN
HEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPEN
PNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQA
TSLSGNGSWTDPVFFYVQAKTGY
Ligand information
>6jk8 Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6jk8 Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis.
Resolution5.0 Å
Binding residue
(original residue number in PDB)		V733 P734 R735 P736
Binding residue
(residue number reindexed from 1)		V664 P665 R666 P667
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6jk8, PDBe:6jk8, PDBj:6jk8
PDBsum6jk8
PubMed32275863
UniProtP08069|IGF1R_HUMAN Insulin-like growth factor 1 receptor (Gene Name=IGF1R)

[Back to BioLiP]